Ayame Misaki plays Miki Saotome, who is a cold young girl who is the polar opposite of Honey, being introverted and anti-social. Like Honey, she has the Honey System installed in her body, changing her into a blue armored form called Sister Miki. In this form she cannot control her aggression, causing her to develop a fear of herself. She stays away from other people because she is afraid of hurting them against her will. Despite her cold demeanor, she cares about Honey. Like Honey, she transforms with the phrase "Honey Flash!" by pressing her personal emblem, a blue spade. However, her transformations are flawed: she draws any loose metal she is in contact with into her body when she flashes, only to pull them out painfully later. Her weapon is a kukri blade called the "Boomerang Bleu."
Ayame Misaki is a gravure idol from Hyogo prefecture. She started modeling with her first photo book Hatsunetsu in 2005. She has since appeared in several photo books and 8 DVDs and won the best gravure prize at the 29th Horipro Talent Scout Caravan. Her role in
Cutey Honey was her biggest to date; she has also released some pop music albums. Her measurements are 36F-24-36 (she only seems petite when standing next to Mikie).